TNF-a Regulates Corneal Langerhans Cell Migration
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منابع مشابه
Enhanced epidermal Langerhans cell migration in IL-10 knockout mice.
The migration of epidermal Langerhans cells (LC) to lymph nodes (LN) is critical in the initiation of contact hypersensitivity (CHS) responses. Studies suggest that contact allergen-induced epidermal proinflammatory cytokines, including IL-1 and TNF-alpha, play important roles in promoting LC migration. Contact allergens also induce epidermal anti-inflammatory cytokines such as IL-10. Since IL-...
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Compared with the peripheral corneal limbus, the human central cornea lacks blood vessels, which is responsible for its immunologically privileged status and high transparency. Dendritic cells (DCs) are present in the central avascular area of inflamed corneas, but the mechanisms of their migration to this location are poorly understood. Here, we investigated the contribution of vessel formatio...
متن کاملLangerhans' cells in guinea pig cornea: response to chemical injury.
Langerhans' cells were observed to migrate into chemically injured corneal epithelium of pigmented and albino guinea pigs in substantial numbers. Whereas the migration of Langerhans' cells was a regular occurrence in both pigmented and nonpigmented animals, the migration of melanocytes occurred in only a portion of the pigmented animals and in fewer numbers. These observations may have signific...
متن کاملLangerhans cell alterations in the guinea pig cornea.
Langerhans cells (LC) are found in virtually all epithelial surfaces, but are rare or absent in the central cornea. LC migration into the cornea can be induced by several different stimuli. The authors studied LC in guinea pig corneal epithelium after: (1) suture placement; (2) suture removal; (3) UV-A irradiation; and (4) UV-C irradiation. Corneal LC markedly increased after suture placement d...
متن کاملCCR5 chemokine receptor mediates recruitment of MHC class II-positive Langerhans cells in the mouse corneal epithelium.
PURPOSE To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-alpha, on the recruitment of MHC class II(+) Langerhans cells (LCs) in the corneal epithelium. METHODS A standard model for corneal LC recruitment, application of cautery to the central corneal surface was used, and the differe...
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تاریخ انتشار 1999